All models are wrong, but some organoids may be useful
نویسندگان
چکیده
منابع مشابه
Essentially all models are wrong, but some are useful.
Recent advances in high-throughput technologies, such as genome-wide SNP analysis and microarray gene expression profiling, have led to a multitude of ranked lists, where the features (SNPs, genes) are sorted based on their individual correlation with a phenotype. Multiple reviews have shown that most such rankings vary considerably across different studies, even in the case of subsampling from...
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As the field of phylogeography has continued to move in the model-based direction, researchers continue struggling to construct useful models for inference. These models must be both simple enough to be tractable yet contain enough of the complexity of the natural world to make meaningful inference. Beyond constructing such models for inference, researchers explore model space and test competin...
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A NESTHESIOLOGISTS are master pharmacologists. In the course of our training, we learn that certain types of drugs, the hypnotics, suppress consciousness. We learn that other types of drugs, the analgesics, suppress nociception. Through training and experience, we learn to induce oblivion with judicious combinations of hypnotics and analgesics. We learn to leverage the synergistic interaction o...
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Species distribution modeling (SDM) is an essential method in ecology and conservation. SDMs are often calibrated within one country's borders, typically along a limited environmental gradient with biased and incomplete data, making the quality of these models questionable. In this study, we evaluated how adequate are national presence-only data for calibrating regional SDMs. We trained SDMs fo...
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LINKED ARTICLES This article is commented on in the editorial by Holford NHG and Anderson BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685-7. doi: 10.1111/bcp.13230 AIM: When different models for weight and age are used in paediatric pharmacokinetic studies it is difficult to compare parameters between studies or perform model-based meta-analyses. This study ...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2019
ISSN: 1474-760X
DOI: 10.1186/s13059-019-1677-4